Risk factors for symptomatic Avascular Necrosis (AVN) in a multi-ethnic Systemic Lupus Erythematosus (SLE) cohort

Avascular necrosis of bone (AVN) is increasingly being recognized as a complication SLE and causes significant disability due to pain mobility limitations. We studied the prevalence factors associated with avascular in multiethnic cohort. patients who visited outpatient clinic from October 2017 April 2019 were considered eligible. Their medical records reviewed identify developed symptomatic AVN, confirmed by either magnetic resonance imaging or plain radiography. Subsequently, their disease characteristics treatment compared did not have AVN. Multivariable logistic regression analyses performed determine independent AVN among A total 390 recruited, majority them females (92.6%); predominantly Malay ethnicity (59.5%), followed Chinese (35.9%) Indian (4.6%). The was 14.1%, mean age diagnosis 37.6 ± 14.4 years. Both univariate multivariable revealed that longer duration, high LDL-C (low density lipoprotein cholesterol), positive anti-cardiolipin (aCL) IgG anti-dsDNA results, history an oral prednisolone dose more than 30 mg daily for at least 4 weeks osteoporotic fractures significantly On other hand, hydroxychloroquin (HCQ), mycophenolate mofetil (MMF) bisphosphonate use lower risk No associations found. In conclusion, several modifiable found be these may used are developing such complications. potential protective effects HCQ, MMF bisphosphonates warrant additional studies.